GIP/GLP-1 peptide reference
Tirzepatide: Reconstitution Math & Reference
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How do you reconstitute tirzepatide?
Tirzepatide reconstitution is the same arithmetic as any lyophilized peptide: divide vial mass (mg) by added bacteriostatic water (ml) to get mg/ml. A 10 mg vial in 2 ml BAC water gives 5 mg/ml — a 2.5 mg target draw is 0.5 ml, or 50 units on a U-100 syringe. Peptly does this instantly with a visual syringe view.
What is Tirzepatide?
Tirzepatide is a dual GIP/GLP-1 receptor agonist — a 39-amino-acid synthetic peptide. It is the active ingredient in Mounjaro and Zepbound.
Tirzepatide is FDA-approved as a prescription medication under brand names including Mounjaro (type-2 diabetes) and Zepbound (chronic weight management). It is the active ingredient in those branded auto-injector pens.
Compounded or research-grade tirzepatide commonly ships as lyophilized powder in vials of 5 mg, 10 mg, 15 mg, 20 mg, or 30 mg. Reconstitution math follows the same vial-mass-over-water-volume formula as every other peptide.
Tirzepatide titration is typically slower than semaglutide (longer step intervals at each dose tier). Peptly's injection log + reminder system handle this without re-entry.
Reconstitution math — reference table
| Vial | BAC water | Concentration | Example dose | U-100 units |
|---|---|---|---|---|
| 5 mg | 1 ml | 5 mg/ml | 2.5 mg | 50 units |
| 10 mg | 1 ml | 10 mg/ml | 2.5 mg | 25 units |
| 10 mg | 2 ml | 5 mg/ml | 5 mg | 100 units |
| 15 mg | 2 ml | 7.5 mg/ml | 7.5 mg | 100 units |
| 20 mg | 2 ml | 10 mg/ml | 10 mg | 100 units |
Storage and shelf-life
Reconstituted tirzepatide is most commonly refrigerated at 2–8 °C and used within 4–6 weeks per common research protocols. Lyophilized powder typically stores at −20 °C until reconstitution.
How Peptly handles Tirzepatide
- Pre-loaded compound profile — no manual entry of vial mass each time.
- Saved reconstitution mixes — reload any combination in one tap.
- Visual U-100 syringe view — see the draw mark before you pull it.
- Injection log — every shot, site, and cycle stored on-device.
- Smart reminders — schedule-aware notifications with site rotation prompts.
Other peptide references
- BPC-157 reconstitution math — BPC-157 is a synthetic pentadecapeptide — a 15-amino-acid fragment derived from a protective protein originally isolated from human gastric juice.
- TB-500 reconstitution math — TB-500 is a 17-amino-acid synthetic peptide fragment of Thymosin Beta-4, a regulatory peptide naturally present in most mammalian cells.
- Semaglutide reconstitution math — Semaglutide is a 31-amino-acid GLP-1 receptor agonist.
- Ipamorelin reconstitution math — Ipamorelin is a 5-amino-acid synthetic peptide and a selective growth hormone secretagogue.
Related tools and guides
- Main peptide calculator overview
- Peptide reconstitution math reference
- BAC water calculator
- Step-by-step reconstitution guide
- Peptide dosage unit reference
- Peptide tracker — injection log
Frequently asked questions
How is tirzepatide reconstitution different from semaglutide? +
The math is identical — both are vial mass divided by BAC water. The practical difference is that tirzepatide dose tiers (commonly 2.5 mg → 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg) are larger than semaglutide tiers, so unit counts are typically in the 25-100 range on a U-100 syringe.
What BAC water volume works for a 10 mg tirzepatide vial? +
Common starting points are 1 ml (giving 10 mg/ml, so a 2.5 mg draw = 25 units) or 2 ml (giving 5 mg/ml, so a 2.5 mg draw = 50 units). Peptly shows the unit count for any combination live.
Can Peptly remind me of my next tirzepatide dose? +
Yes. In Peptly Pro, you can schedule a weekly dose with smart reminders. The schedule supports titration steps (changing dose over time).
Does the visual syringe view show partial-unit marks? +
Peptly's visual syringe shows half-unit precision visually. For a draw like 12.5 units, the indicator lands between the 12 and 13 unit marks.
Is tirzepatide approved for human use? +
Yes — tirzepatide is FDA-approved under brand names including Mounjaro and Zepbound. Compounded or research-grade vials are a different supply category. Peptly is a calculator and reference, not a prescription substitute.