Triple-agonist peptide reference
Retatrutide: Reconstitution Math & Reference
By Baris Bingor · Last updated
How do you reconstitute retatrutide?
Retatrutide reconstitution is the same arithmetic as any lyophilized peptide: divide vial mass (mg) by added bacteriostatic water (ml) to get mg/ml. A 10 mg vial in 2 ml BAC water yields 5 mg/ml — so a 2 mg target draw is 0.4 ml, or 40 units on a U-100 syringe. The calculator below does it for any numbers you type.
Reconstitution calculator
Type your own numbers. They aren't sent anywhere: the math runs in your browser.
Type an amount to see the volume and the units.
Arithmetic only. Peptly does not suggest amounts: the amount is yours, from your protocol or the product's documentation. Not medical advice.
What is Retatrutide?
Retatrutide (LY3437943) is an investigational triple-hormone-receptor agonist — it targets the GLP-1, GIP, AND glucagon receptors. It is a synthetic peptide still in clinical trials.
Retatrutide is investigational and NOT FDA-approved — it remains in clinical trials. A 2023 Phase 2 trial published in the New England Journal of Medicine reported mean weight reductions up to roughly 24% at 48 weeks on the highest (12 mg) dose. This page is a math reference for research, not a prescription substitute or dosing advice.
As a triple agonist (GLP-1 + GIP + glucagon), retatrutide is distinct from dual agonists like tirzepatide (GLP-1 + GIP) and single GLP-1 agonists like semaglutide. There is no FDA-approved titration schedule; research protocols follow the published trial literature.
Research-grade retatrutide commonly ships as 5 mg or 10 mg lyophilized powder. The reconstitution math is identical to every other peptide — concentration = vial mass ÷ BAC water. In the Peptly app, retatrutide has its own plain-language profile in the library, with no amounts.
Reconstitution math — reference table
| Vial | BAC water | Concentration | Example dose | U-100 units |
|---|---|---|---|---|
| 5 mg | 1 ml | 5 mg/ml | 1 mg | 20 units |
| 5 mg | 2 ml | 2.5 mg/ml | 1 mg | 40 units |
| 10 mg | 2 ml | 5 mg/ml | 2 mg | 40 units |
| 10 mg | 2 ml | 5 mg/ml | 4 mg | 80 units |
| 10 mg | 5 ml | 2 mg/ml | 2 mg | 100 units |
Storage and shelf-life
Reconstituted GLP-1-class peptides are most commonly refrigerated at 2–8 °C and used within 4–6 weeks per common research protocols. Lyophilized powder typically stores at −20 °C until reconstitution.
Retatrutide in the Peptly app
- A plain-language profile in the library — no amounts, frequencies or regimens.
- Entries exactly as you type them — the app never calculates, converts or suggests an amount.
- Today and reminders — log or skip each entry in one tap, on the schedule you set.
- Injection-site rotation — Peptly suggests the site you used longest ago, other than the last one.
- Private by design — no account; your log stays on your phone.
Other peptide references
- BPC-157 reconstitution math — BPC-157 is a synthetic pentadecapeptide — a 15-amino-acid fragment derived from a protective protein originally isolated from human gastric juice.
- TB-500 reconstitution math — TB-500 is a 17-amino-acid synthetic peptide fragment of Thymosin Beta-4, a regulatory peptide naturally present in most mammalian cells.
- Semaglutide reconstitution math — Semaglutide is a 31-amino-acid GLP-1 receptor agonist.
- Tirzepatide reconstitution math — Tirzepatide is a dual GIP/GLP-1 receptor agonist — a 39-amino-acid synthetic peptide.
- Ipamorelin reconstitution math — Ipamorelin is a 5-amino-acid synthetic peptide and a selective growth hormone secretagogue.
- CJC-1295 reconstitution math — CJC-1295 is a synthetic 30-amino-acid analog of growth hormone-releasing hormone (GHRH 1-29), modified for protease resistance.
- Tesamorelin reconstitution math — Tesamorelin is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH 1-44), stabilized with a trans-3-hexenoic acid group.
- GHK-Cu reconstitution math — GHK-Cu is a copper complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), which binds a single copper(II) ion.
Related tools and guides
- Main peptide calculator overview
- Peptide reconstitution math reference
- BAC water calculator
- Step-by-step reconstitution guide
- Peptide storage & refrigeration guide
- Peptide dosage unit reference
- Peptide tracker — injection log
Frequently asked questions
How is retatrutide different from tirzepatide and semaglutide? +
Retatrutide is a triple agonist (GLP-1 + GIP + glucagon). Tirzepatide is a dual agonist (GLP-1 + GIP); semaglutide is a single GLP-1 agonist. The reconstitution math is identical for all three — only the receptor targets and dose ranges differ.
What BAC water volume works for a 10 mg retatrutide vial? +
Common starting points are 1 ml (10 mg/ml) or 2 ml (5 mg/ml). At 5 mg/ml, a 2 mg research draw is 40 units on a U-100 syringe. The calculator on this page shows the unit count for any vial × water combination as you type.
Is there an approved retatrutide dosing schedule? +
No. Retatrutide is investigational and has no FDA-approved label or titration schedule. Research protocols follow the published clinical-trial literature. Peptly does not recommend a dose: the calculator on this page only does the reconstitution arithmetic, and the Peptly app only keeps what you enter.
Can Peptly log retatrutide entries? +
Yes. Log each entry with the amount exactly as you typed it, with a reminder from your own weekly schedule and a suggested next injection site; your history keeps retatrutide apart from any other peptide. Peptly never suggests an amount.
Is retatrutide approved for human use? +
No. Retatrutide (LY3437943) is investigational and not FDA-approved; it remains in clinical trials. This page is a math reference and the Peptly app is a log — neither is medical advice. Consult a licensed clinician for any health decision.