GHRH peptide reference
Tesamorelin: Reconstitution Math & Reference
By Baris Bingor · Last updated
How do you reconstitute tesamorelin?
Tesamorelin reconstitution is arithmetic: divide the vial mass (mg) by the water added (ml) to get mg/ml. A 5 mg vial with 1 ml water yields 5 mg/ml — so the FDA-approved 2 mg dose is 0.4 ml, or 40 units on a U-100 insulin syringe. The calculator below does it for any numbers you type.
Reconstitution calculator
Type your own numbers. They aren't sent anywhere: the math runs in your browser.
Type an amount to see the volume and the units.
Arithmetic only. Peptly does not suggest amounts: the amount is yours, from your protocol or the product's documentation. Not medical advice.
What is Tesamorelin?
Tesamorelin is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH 1-44), stabilized with a trans-3-hexenoic acid group. It is FDA-approved as Egrifta and Egrifta SV.
Tesamorelin is the rare research-discussed GHRH analog that is actually FDA-approved: marketed as Egrifta (2010) and later Egrifta SV, it is indicated for the reduction of excess abdominal fat in people with HIV-associated lipodystrophy. That distinguishes it from GHRH analogs like CJC-1295, which are NOT FDA-approved. This page is a math reference for research — not a prescription substitute or dosing advice.
Structurally, tesamorelin is the full 44-amino-acid human GHRH(1-44) sequence with a trans-3-hexenoic acid modification at the N-terminus that improves metabolic stability and resistance to enzymatic breakdown. The approved subcutaneous dose is 2 mg once daily. Compounded or research-grade tesamorelin commonly ships as 2 mg, 5 mg, or 10 mg lyophilized vials.
The reconstitution arithmetic is identical to every other lyophilized peptide — concentration equals vial mass divided by the water volume added. The approved Egrifta SV presentation is reconstituted with sterile water; research-grade vials typically use bacteriostatic water. In the Peptly app, tesamorelin has its own plain-language profile in the library.
Reconstitution math — reference table
| Vial | BAC water | Concentration | Example dose | U-100 units |
|---|---|---|---|---|
| 2 mg | 1 ml | 2 mg/ml | 2 mg | 100 units |
| 5 mg | 1 ml | 5 mg/ml | 2 mg | 40 units |
| 5 mg | 2 ml | 2.5 mg/ml | 2 mg | 80 units |
| 10 mg | 2 ml | 5 mg/ml | 2 mg | 40 units |
| 10 mg | 5 ml | 2 mg/ml | 2 mg | 100 units |
Storage and shelf-life
The approved Egrifta SV label directs that the reconstituted solution be injected immediately. Research protocols using compounded tesamorelin most commonly refrigerate the reconstituted solution at 2–8 °C and use it within 2–4 weeks. Lyophilized powder is typically stored refrigerated or frozen until reconstitution.
Tesamorelin in the Peptly app
- A plain-language profile in the library — no amounts, frequencies or regimens.
- Entries exactly as you type them — the app never calculates, converts or suggests an amount.
- Today and reminders — log or skip each entry in one tap, on the schedule you set.
- Injection-site rotation — Peptly suggests the site you used longest ago, other than the last one.
- Private by design — no account; your log stays on your phone.
Other peptide references
- BPC-157 reconstitution math — BPC-157 is a synthetic pentadecapeptide — a 15-amino-acid fragment derived from a protective protein originally isolated from human gastric juice.
- TB-500 reconstitution math — TB-500 is a 17-amino-acid synthetic peptide fragment of Thymosin Beta-4, a regulatory peptide naturally present in most mammalian cells.
- Semaglutide reconstitution math — Semaglutide is a 31-amino-acid GLP-1 receptor agonist.
- Tirzepatide reconstitution math — Tirzepatide is a dual GIP/GLP-1 receptor agonist — a 39-amino-acid synthetic peptide.
- Ipamorelin reconstitution math — Ipamorelin is a 5-amino-acid synthetic peptide and a selective growth hormone secretagogue.
- CJC-1295 reconstitution math — CJC-1295 is a synthetic 30-amino-acid analog of growth hormone-releasing hormone (GHRH 1-29), modified for protease resistance.
- Retatrutide reconstitution math — Retatrutide (LY3437943) is an investigational triple-hormone-receptor agonist — it targets the GLP-1, GIP, AND glucagon receptors.
- GHK-Cu reconstitution math — GHK-Cu is a copper complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), which binds a single copper(II) ion.
Related tools and guides
- Main peptide calculator overview
- Peptide reconstitution math reference
- BAC water calculator
- Step-by-step reconstitution guide
- Peptide storage & refrigeration guide
- Peptide dosage unit reference
- Peptide tracker — injection log
Frequently asked questions
Is tesamorelin FDA-approved? +
Yes. Tesamorelin is FDA-approved as Egrifta (2010) and Egrifta SV for the reduction of excess abdominal fat in people with HIV-associated lipodystrophy. That makes it unusual among research-discussed GHRH analogs — CJC-1295, for example, is not approved. This page is a math reference and the Peptly app is a log — neither is a prescription substitute.
How is tesamorelin different from CJC-1295? +
Both are GHRH analogs, but tesamorelin is the full 44-amino-acid GHRH(1-44) sequence and is FDA-approved, while CJC-1295 is a 30-amino-acid GHRH(1-29) analog that is not approved. The reconstitution math is identical for both — concentration = vial mass ÷ water volume.
What water volume works for a 5 mg tesamorelin vial? +
Common choices are 1 ml (giving 5 mg/ml, so the 2 mg dose lands at 40 units on a U-100 syringe) or 2 ml (2.5 mg/ml, 2 mg = 80 units). The calculator on this page shows the unit count for any vial × water combination as you type.
What is the approved tesamorelin dose? +
The Egrifta / Egrifta SV label specifies 2 mg injected subcutaneously once daily. Research protocols vary. Peptly does not recommend a dose: the calculator on this page only does the reconstitution arithmetic for the vial and water volume you enter, and the Peptly app only keeps what you log.
Can Peptly remind me on a daily tesamorelin schedule? +
Yes. Set a daily schedule and Peptly reminds you when each entry is due; log or skip it from Today, and it suggests your next injection site. Your history keeps tesamorelin apart from any other peptide.