GHRH peptide reference
Tesamorelin: Reconstitution Math & Reference
By Baris Bingor · Last updated
How do you reconstitute tesamorelin?
Tesamorelin reconstitution is arithmetic: divide the vial mass (mg) by the water added (ml) to get mg/ml. A 5 mg vial with 1 ml water yields 5 mg/ml — so the FDA-approved 2 mg dose is 0.4 ml, or 40 units on a U-100 insulin syringe. Peptly computes this instantly with a visual draw indicator.
What is Tesamorelin?
Tesamorelin is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH 1-44), stabilized with a trans-3-hexenoic acid group. It is FDA-approved as Egrifta and Egrifta SV.
Tesamorelin is the rare research-discussed GHRH analog that is actually FDA-approved: marketed as Egrifta (2010) and later Egrifta SV, it is indicated for the reduction of excess abdominal fat in people with HIV-associated lipodystrophy. That distinguishes it from GHRH analogs like CJC-1295, which are NOT FDA-approved. Peptly is a calculator for research and reference — not a prescription substitute or dosing advice.
Structurally, tesamorelin is the full 44-amino-acid human GHRH(1-44) sequence with a trans-3-hexenoic acid modification at the N-terminus that improves metabolic stability and resistance to enzymatic breakdown. The approved subcutaneous dose is 2 mg once daily. Compounded or research-grade tesamorelin commonly ships as 2 mg, 5 mg, or 10 mg lyophilized vials.
The reconstitution arithmetic is identical to every other lyophilized peptide — concentration equals vial mass divided by the water volume added. The approved Egrifta SV presentation is reconstituted with sterile water; research-grade vials typically use bacteriostatic water. Peptly tracks tesamorelin as its own profile with saved reconstitution mixes and an injection log.
Reconstitution math — reference table
| Vial | BAC water | Concentration | Example dose | U-100 units |
|---|---|---|---|---|
| 2 mg | 1 ml | 2 mg/ml | 2 mg | 100 units |
| 5 mg | 1 ml | 5 mg/ml | 2 mg | 40 units |
| 5 mg | 2 ml | 2.5 mg/ml | 2 mg | 80 units |
| 10 mg | 2 ml | 5 mg/ml | 2 mg | 40 units |
| 10 mg | 5 ml | 2 mg/ml | 2 mg | 100 units |
Storage and shelf-life
The approved Egrifta SV label directs that the reconstituted solution be injected immediately. Research protocols using compounded tesamorelin most commonly refrigerate the reconstituted solution at 2–8 °C and use it within 2–4 weeks. Lyophilized powder is typically stored refrigerated or frozen until reconstitution.
How Peptly handles Tesamorelin
- Pre-loaded compound profile — no manual entry of vial mass each time.
- Saved reconstitution mixes — reload any combination in one tap.
- Visual U-100 syringe view — see the draw mark before you pull it.
- Injection log — every shot, site, and cycle stored on-device.
- Smart reminders — schedule-aware notifications with site rotation prompts.
Other peptide references
- BPC-157 reconstitution math — BPC-157 is a synthetic pentadecapeptide — a 15-amino-acid fragment derived from a protective protein originally isolated from human gastric juice.
- TB-500 reconstitution math — TB-500 is a 17-amino-acid synthetic peptide fragment of Thymosin Beta-4, a regulatory peptide naturally present in most mammalian cells.
- Semaglutide reconstitution math — Semaglutide is a 31-amino-acid GLP-1 receptor agonist.
- Tirzepatide reconstitution math — Tirzepatide is a dual GIP/GLP-1 receptor agonist — a 39-amino-acid synthetic peptide.
- Ipamorelin reconstitution math — Ipamorelin is a 5-amino-acid synthetic peptide and a selective growth hormone secretagogue.
- CJC-1295 reconstitution math — CJC-1295 is a synthetic 30-amino-acid analog of growth hormone-releasing hormone (GHRH 1-29), modified for protease resistance.
- Retatrutide reconstitution math — Retatrutide (LY3437943) is an investigational triple-hormone-receptor agonist — it targets the GLP-1, GIP, AND glucagon receptors.
- GHK-Cu reconstitution math — GHK-Cu is a copper complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), which binds a single copper(II) ion.
Related tools and guides
- Main peptide calculator overview
- Peptide reconstitution math reference
- BAC water calculator
- Step-by-step reconstitution guide
- Peptide storage & refrigeration guide
- Peptide dosage unit reference
- Peptide tracker — injection log
Frequently asked questions
Is tesamorelin FDA-approved? +
Yes. Tesamorelin is FDA-approved as Egrifta (2010) and Egrifta SV for the reduction of excess abdominal fat in people with HIV-associated lipodystrophy. That makes it unusual among research-discussed GHRH analogs — CJC-1295, for example, is not approved. Peptly is a calculator and reference, not a prescription substitute.
How is tesamorelin different from CJC-1295? +
Both are GHRH analogs, but tesamorelin is the full 44-amino-acid GHRH(1-44) sequence and is FDA-approved, while CJC-1295 is a 30-amino-acid GHRH(1-29) analog that is not approved. The reconstitution math is identical for both — concentration = vial mass ÷ water volume.
What water volume works for a 5 mg tesamorelin vial? +
Common choices are 1 ml (giving 5 mg/ml, so the 2 mg dose lands at 40 units on a U-100 syringe) or 2 ml (2.5 mg/ml, 2 mg = 80 units). Peptly shows the unit count for any vial × water combination live as you adjust the slider.
What is the approved tesamorelin dose? +
The Egrifta / Egrifta SV label specifies 2 mg injected subcutaneously once daily. Research protocols vary. Peptly does not recommend a dose — it only performs the reconstitution arithmetic for whatever vial and water volume you enter.
Can Peptly track a daily tesamorelin schedule? +
Yes. In Peptly Pro you can save the reconstitution mix and log each daily shot with reminders and injection-site rotation. The History view keeps tesamorelin separate from any other peptide profile.